ChloroquineV1, Main, Exploration, bibRecord, 000527

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

Identifieur interne : 000527 ( Main/Exploration ); précédent : 000526; suivant : 000528

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

Source :

Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2019.

RBID : PMC:6877958

Abstract

The high recurrence frequency of gliomas but deficiency of effective treatment and prevalent chemoresistance have elicited interests in exploring and developing new agents. Paris polyphyllins are monomers extracted from rhizome of Paris polyphylla var. yunnanensis. Here, we first reported that polyphyllin VII (PP7) exhibited cytotoxic effect on glioma cells. PP7 significantly suppressed the viability and induced cell death of U87-MG and U251 cells after 24 h, with the IC50 values 4.24 ± 0.87 μM and 2.17 ± 0.14 μM, respectively. Both apoptotic and autophagic processes were involved in the cytotoxic effect of PP7, as PP7 activated the Bcl2/Bax pathway and the inhibition of autophagy partly rescued the toxicity of PP7 in glioma cells. In addition, an inhibition of AKT/mTORC1 activity was found after PP7 administration, and it seemed that the overproduction of reactive oxygen species (ROS) was responsible for this effect. Namely, the removal of ROS by NAC treatment mitigated PP7-induced cell death, autophagy, and its effect on the AKT/mTORC1 signaling. Additionally, a combination assay of PP7 with temozolomide (TMZ), the most used chemotherapy for glioma patients, was performed resulting in synergism, while PP7 reduced TMZ resistance through inhibition of MGMT expression. Thus, our study reports PP7 as a potential agent for glioma treatment and reveals its underlying mechanisms of action.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877958

DOI: 10.1155/2019/1805635
PubMed: 31814867
PubMed Central: 6877958

Affiliations:

République populaire de Chine

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide</title>
<author><name sortKey="Pang, Dejiang" sort="Pang, Dejiang" uniqKey="Pang D" first="Dejiang" last="Pang">Dejiang Pang</name>
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<author><name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
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<author><name sortKey="Yang, Chengcheng" sort="Yang, Chengcheng" uniqKey="Yang C" first="Chengcheng" last="Yang">Chengcheng Yang</name>
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<author><name sortKey="Feng, Bin" sort="Feng, Bin" uniqKey="Feng B" first="Bin" last="Feng">Bin Feng</name>
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<author><name sortKey="Li, Lixia" sort="Li, Lixia" uniqKey="Li L" first="Lixia" last="Li">Lixia Li</name>
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<author><name sortKey="Liu, Wentao" sort="Liu, Wentao" uniqKey="Liu W" first="Wentao" last="Liu">Wentao Liu</name>
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<author><name sortKey="Geng, Yi" sort="Geng, Yi" uniqKey="Geng Y" first="Yi" last="Geng">Yi Geng</name>
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<author><name sortKey="Luo, Qihui" sort="Luo, Qihui" uniqKey="Luo Q" first="Qihui" last="Luo">Qihui Luo</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<affiliation wicri:level="1"><nlm:aff id="I3">Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130</wicri:regionArea>
<wicri:noRegion>Chengdu 611130</wicri:noRegion>
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</author>
<author><name sortKey="Chen, Zhengli" sort="Chen, Zhengli" uniqKey="Chen Z" first="Zhengli" last="Chen">Zhengli Chen</name>
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<affiliation wicri:level="1"><nlm:aff id="I3">Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130</wicri:regionArea>
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<author><name sortKey="Huang, Chao" sort="Huang, Chao" uniqKey="Huang C" first="Chao" last="Huang">Chao Huang</name>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I3">Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130</wicri:regionArea>
<wicri:noRegion>Chengdu 611130</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Oxidative Medicine and Cellular Longevity</title>
<idno type="ISSN">1942-0900</idno>
<idno type="eISSN">1942-0994</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>The high recurrence frequency of gliomas but deficiency of effective treatment and prevalent chemoresistance have elicited interests in exploring and developing new agents. Paris polyphyllins are monomers extracted from rhizome of Paris polyphylla var. yunnanensis. Here, we first reported that polyphyllin VII (PP7) exhibited cytotoxic effect on glioma cells. PP7 significantly suppressed the viability and induced cell death of U87-MG and U251 cells after 24 h, with the IC50 values 4.24 ± 0.87 <italic>μ</italic>
M and 2.17 ± 0.14 <italic>μ</italic>
M, respectively. Both apoptotic and autophagic processes were involved in the cytotoxic effect of PP7, as PP7 activated the Bcl2/Bax pathway and the inhibition of autophagy partly rescued the toxicity of PP7 in glioma cells. In addition, an inhibition of AKT/mTORC1 activity was found after PP7 administration, and it seemed that the overproduction of reactive oxygen species (ROS) was responsible for this effect. Namely, the removal of ROS by NAC treatment mitigated PP7-induced cell death, autophagy, and its effect on the AKT/mTORC1 signaling. Additionally, a combination assay of PP7 with temozolomide (TMZ), the most used chemotherapy for glioma patients, was performed resulting in synergism, while PP7 reduced TMZ resistance through inhibition of MGMT expression. Thus, our study reports PP7 as a potential agent for glioma treatment and reveals its underlying mechanisms of action.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hu, J" uniqKey="Hu J">J. Hu</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X. Cao</name>
</author>
<author><name sortKey="Pang, D" uniqKey="Pang D">D. Pang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rock, K" uniqKey="Rock K">K. Rock</name>
</author>
<author><name sortKey="Mcardle, O" uniqKey="Mcardle O">O. McArdle</name>
</author>
<author><name sortKey="Forde, P" uniqKey="Forde P">P. Forde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stupp, R" uniqKey="Stupp R">R. Stupp</name>
</author>
<author><name sortKey="Mason, W P" uniqKey="Mason W">W. P. Mason</name>
</author>
<author><name sortKey="Van Den Bent, M J" uniqKey="Van Den Bent M">M. J. van den Bent</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ostrom, Q T" uniqKey="Ostrom Q">Q. T. Ostrom</name>
</author>
<author><name sortKey="Gittleman, H" uniqKey="Gittleman H">H. Gittleman</name>
</author>
<author><name sortKey="Truitt, G" uniqKey="Truitt G">G. Truitt</name>
</author>
<author><name sortKey="Boscia, A" uniqKey="Boscia A">A. Boscia</name>
</author>
<author><name sortKey="Kruchko, C" uniqKey="Kruchko C">C. Kruchko</name>
</author>
<author><name sortKey="Barnholtz Sloan, J S" uniqKey="Barnholtz Sloan J">J. S. Barnholtz-Sloan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daniel, P" uniqKey="Daniel P">P. Daniel</name>
</author>
<author><name sortKey="Sabri, S" uniqKey="Sabri S">S. Sabri</name>
</author>
<author><name sortKey="Chaddad, A" uniqKey="Chaddad A">A. Chaddad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Faje, A T" uniqKey="Faje A">A. T. Faje</name>
</author>
<author><name sortKey="Nachtigall, L" uniqKey="Nachtigall L">L. Nachtigall</name>
</author>
<author><name sortKey="Wexler, D" uniqKey="Wexler D">D. Wexler</name>
</author>
<author><name sortKey="Miller, K K" uniqKey="Miller K">K. K. Miller</name>
</author>
<author><name sortKey="Klibanski, A" uniqKey="Klibanski A">A. Klibanski</name>
</author>
<author><name sortKey="Makimura, H" uniqKey="Makimura H">H. Makimura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Compendium, E M" uniqKey="Compendium E">E. M. Compendium</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Head, R J" uniqKey="Head R">R. J. Head</name>
</author>
<author><name sortKey="Fay, M F" uniqKey="Fay M">M. F. Fay</name>
</author>
<author><name sortKey="Cosgrove, L" uniqKey="Cosgrove L">L. Cosgrove</name>
</author>
<author><name sortKey="Fung, K Y C" uniqKey="Fung K">K. Y. C. Fung</name>
</author>
<author><name sortKey="Rundle Thiele, D" uniqKey="Rundle Thiele D">D. Rundle-Thiele</name>
</author>
<author><name sortKey="Martin, J H" uniqKey="Martin J">J. H. Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarkaria, J N" uniqKey="Sarkaria J">J. N. Sarkaria</name>
</author>
<author><name sortKey="Kitange, G J" uniqKey="Kitange G">G. J. Kitange</name>
</author>
<author><name sortKey="James, C D" uniqKey="James C">C. D. James</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Li, N" uniqKey="Li N">N. Li</name>
</author>
<author><name sortKey="Gao, W" uniqKey="Gao W">W. Gao</name>
</author>
<author><name sortKey="Man, S" uniqKey="Man S">S. Man</name>
</author>
<author><name sortKey="Yin, S" uniqKey="Yin S">S. Yin</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deng, D" uniqKey="Deng D">D. Deng</name>
</author>
<author><name sortKey="Lauren, D" uniqKey="Lauren D">D. Lauren</name>
</author>
<author><name sortKey="Cooney, J" uniqKey="Cooney J">J. Cooney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shah, S A" uniqKey="Shah S">S. A. Shah</name>
</author>
<author><name sortKey="Mazumder, P B" uniqKey="Mazumder P">P. B. Mazumder</name>
</author>
<author><name sortKey="Choudhury, M D" uniqKey="Choudhury M">M. D. Choudhury</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name>
</author>
<author><name sortKey="Wu, J J" uniqKey="Wu J">J. J. Wu</name>
</author>
<author><name sortKey="Zheng, F" uniqKey="Zheng F">F. Zheng</name>
</author>
<author><name sortKey="Tang, Q" uniqKey="Tang Q">Q. Tang</name>
</author>
<author><name sortKey="Wu, W Y" uniqKey="Wu W">W. Y. Wu</name>
</author>
<author><name sortKey="Hann, S S" uniqKey="Hann S">S. S. Hann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shi, Y M" uniqKey="Shi Y">Y.-M. Shi</name>
</author>
<author><name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name>
</author>
<author><name sortKey="Geng, Y D" uniqKey="Geng Y">Y.-D. Geng</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name>
</author>
<author><name sortKey="Kong, L Y" uniqKey="Kong L">L.-Y. Kong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gu, L" uniqKey="Gu L">L. Gu</name>
</author>
<author><name sortKey="Feng, J" uniqKey="Feng J">J. Feng</name>
</author>
<author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name>
</author>
<author><name sortKey="Luo, M" uniqKey="Luo M">M. Luo</name>
</author>
<author><name sortKey="Su, D" uniqKey="Su D">D. Su</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, J" uniqKey="Chang J">J. Chang</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, M S" uniqKey="Lee M">M. S. Lee</name>
</author>
<author><name sortKey="Chan, J Y W" uniqKey="Chan J">J. Y. W. Chan</name>
</author>
<author><name sortKey="Kong, S K" uniqKey="Kong S">S. K. Kong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Q" uniqKey="Yu Q">Q. Yu</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name>
</author>
<author><name sortKey="Lu, P" uniqKey="Lu P">P. Lu</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Z" uniqKey="Lin Z">Z. Lin</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Li, F" uniqKey="Li F">F. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name>
</author>
<author><name sortKey="Jia, X" uniqKey="Jia X">X. Jia</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, D X" uniqKey="He D">D. X. He</name>
</author>
<author><name sortKey="Li, G H" uniqKey="Li G">G. H. Li</name>
</author>
<author><name sortKey="Gu, X T" uniqKey="Gu X">X. T. Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fan, L" uniqKey="Fan L">L. Fan</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, L" uniqKey="Wei L">L. Wei</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name>
</author>
<author><name sortKey="Qiao, C" uniqKey="Qiao C">C. Qiao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ni, H M" uniqKey="Ni H">H.-M. Ni</name>
</author>
<author><name sortKey="Bockus, A" uniqKey="Bockus A">A. Bockus</name>
</author>
<author><name sortKey="Wozniak, A L" uniqKey="Wozniak A">A. L. Wozniak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosse, T" uniqKey="Rosse T">T. Rossé</name>
</author>
<author><name sortKey="Olivier, R" uniqKey="Olivier R">R. Olivier</name>
</author>
<author><name sortKey="Monney, L" uniqKey="Monney L">L. Monney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chipuk, J E" uniqKey="Chipuk J">J. E. Chipuk</name>
</author>
<author><name sortKey="Mcstay, G P" uniqKey="Mcstay G">G. P. McStay</name>
</author>
<author><name sortKey="Bharti, A" uniqKey="Bharti A">A. Bharti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azad, M B" uniqKey="Azad M">M. B. Azad</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Gibson, S B" uniqKey="Gibson S">S. B. Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B. Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hippert, M M" uniqKey="Hippert M">M. M. Hippert</name>
</author>
<author><name sortKey="O Toole, P S" uniqKey="O Toole P">P. S. O'Toole</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A. Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arico, S" uniqKey="Arico S">S. Arico</name>
</author>
<author><name sortKey="Petiot, A" uniqKey="Petiot A">A. Petiot</name>
</author>
<author><name sortKey="Bauvy, C" uniqKey="Bauvy C">C. Bauvy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, Z" uniqKey="Feng Z">Z. Feng</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name>
</author>
<author><name sortKey="Levine, A J" uniqKey="Levine A">A. J. Levine</name>
</author>
<author><name sortKey="Jin, S" uniqKey="Jin S">S. Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yue, Z" uniqKey="Yue Z">Z. Yue</name>
</author>
<author><name sortKey="Jin, S" uniqKey="Jin S">S. Jin</name>
</author>
<author><name sortKey="Yang, C" uniqKey="Yang C">C. Yang</name>
</author>
<author><name sortKey="Levine, A J" uniqKey="Levine A">A. J. Levine</name>
</author>
<author><name sortKey="Heintz, N" uniqKey="Heintz N">N. Heintz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Camphausen, K" uniqKey="Camphausen K">K. Camphausen</name>
</author>
<author><name sortKey="Purow, B" uniqKey="Purow B">B. Purow</name>
</author>
<author><name sortKey="Sproull, M" uniqKey="Sproull M">M. Sproull</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name>
</author>
<author><name sortKey="Lei, B" uniqKey="Lei B">B. Lei</name>
</author>
<author><name sortKey="Xiang, W" uniqKey="Xiang W">W. Xiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schieber, M" uniqKey="Schieber M">M. Schieber</name>
</author>
<author><name sortKey="Chandel, N S" uniqKey="Chandel N">N. S. Chandel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, L" uniqKey="Raj L">L. Raj</name>
</author>
<author><name sortKey="Ide, T" uniqKey="Ide T">T. Ide</name>
</author>
<author><name sortKey="Gurkar, A U" uniqKey="Gurkar A">A. U. Gurkar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manning, B D" uniqKey="Manning B">B. D. Manning</name>
</author>
<author><name sortKey="Cantley, L C" uniqKey="Cantley L">L. C. Cantley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yalcin, S" uniqKey="Yalcin S">S. Yalcin</name>
</author>
<author><name sortKey="Marinkovic, D" uniqKey="Marinkovic D">D. Marinkovic</name>
</author>
<author><name sortKey="Mungamuri, S K" uniqKey="Mungamuri S">S. K. Mungamuri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shearn, C T" uniqKey="Shearn C">C. T. Shearn</name>
</author>
<author><name sortKey="Smathers, R L" uniqKey="Smathers R">R. L. Smathers</name>
</author>
<author><name sortKey="Stewart, B J" uniqKey="Stewart B">B. J. Stewart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiarugi, P" uniqKey="Chiarugi P">P. Chiarugi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murata, H" uniqKey="Murata H">H. Murata</name>
</author>
<author><name sortKey="Ihara, Y" uniqKey="Ihara Y">Y. Ihara</name>
</author>
<author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H. Nakamura</name>
</author>
<author><name sortKey="Yodoi, J" uniqKey="Yodoi J">J. Yodoi</name>
</author>
<author><name sortKey="Sumikawa, K" uniqKey="Sumikawa K">K. Sumikawa</name>
</author>
<author><name sortKey="Kondo, T" uniqKey="Kondo T">T. Kondo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Makhov, P" uniqKey="Makhov P">P. Makhov</name>
</author>
<author><name sortKey="Golovine, K" uniqKey="Golovine K">K. Golovine</name>
</author>
<author><name sortKey="Teper, E" uniqKey="Teper E">E. Teper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shearn, C T" uniqKey="Shearn C">C. T. Shearn</name>
</author>
<author><name sortKey="Fritz, K S" uniqKey="Fritz K">K. S. Fritz</name>
</author>
<author><name sortKey="Reigan, P" uniqKey="Reigan P">P. Reigan</name>
</author>
<author><name sortKey="Petersen, D R" uniqKey="Petersen D">D. R. Petersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
<author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gozuacik, D" uniqKey="Gozuacik D">D. Gozuacik</name>
</author>
<author><name sortKey="Kimchi, A" uniqKey="Kimchi A">A. Kimchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouyang, L" uniqKey="Ouyang L">L. Ouyang</name>
</author>
<author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name>
</author>
<author><name sortKey="Zhao, S" uniqKey="Zhao S">S. Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martina, J A" uniqKey="Martina J">J. A. Martina</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Gucek, M" uniqKey="Gucek M">M. Gucek</name>
</author>
<author><name sortKey="Puertollano, R" uniqKey="Puertollano R">R. Puertollano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Y T" uniqKey="Wu Y">Y.-T. Wu</name>
</author>
<author><name sortKey="Tan, H L" uniqKey="Tan H">H.-L. Tan</name>
</author>
<author><name sortKey="Shui, G" uniqKey="Shui G">G. Shui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Redmann, M" uniqKey="Redmann M">M. Redmann</name>
</author>
<author><name sortKey="Benavides, G A" uniqKey="Benavides G">G. A. Benavides</name>
</author>
<author><name sortKey="Berryhill, T F" uniqKey="Berryhill T">T. F. Berryhill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Margison, G P" uniqKey="Margison G">G. P. Margison</name>
</author>
<author><name sortKey="Santibanez Koref, M F" uniqKey="Santibanez Koref M">M. F. Santibanez Koref</name>
</author>
<author><name sortKey="Povey, A C" uniqKey="Povey A">A. C. Povey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fan, C H" uniqKey="Fan C">C. H. Fan</name>
</author>
<author><name sortKey="Liu, W L" uniqKey="Liu W">W. L. Liu</name>
</author>
<author><name sortKey="Cao, H" uniqKey="Cao H">H. Cao</name>
</author>
<author><name sortKey="Wen, C" uniqKey="Wen C">C. Wen</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
<author><name sortKey="Jiang, G" uniqKey="Jiang G">G. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
<author><name sortKey="Liang, R F" uniqKey="Liang R">R. F. Liang</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Mao, Q" uniqKey="Mao Q">Q. Mao</name>
</author>
<author><name sortKey="Liu, Y H" uniqKey="Liu Y">Y. H. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quinn, J A" uniqKey="Quinn J">J. A. Quinn</name>
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<author><name sortKey="Jiang, S X" uniqKey="Jiang S">S. X. Jiang</name>
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<author><name sortKey="Reardon, D A" uniqKey="Reardon D">D. A. Reardon</name>
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<biblStruct><analytic><author><name sortKey="Turriziani, M" uniqKey="Turriziani M">M. Turriziani</name>
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<author><name sortKey="Caporaso, P" uniqKey="Caporaso P">P. Caporaso</name>
</author>
<author><name sortKey="Bonmassar, L" uniqKey="Bonmassar L">L. Bonmassar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, L H" uniqKey="Zhang L">L.-H. Zhang</name>
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<author><name sortKey="Yin, A A" uniqKey="Yin A">A.-A. Yin</name>
</author>
<author><name sortKey="Cheng, J X" uniqKey="Cheng J">J.-X. Cheng</name>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Pang, Dejiang" sort="Pang, Dejiang" uniqKey="Pang D" first="Dejiang" last="Pang">Dejiang Pang</name>
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<name sortKey="Chen, Zhengli" sort="Chen, Zhengli" uniqKey="Chen Z" first="Zhengli" last="Chen">Zhengli Chen</name>
<name sortKey="Chen, Zhengli" sort="Chen, Zhengli" uniqKey="Chen Z" first="Zhengli" last="Chen">Zhengli Chen</name>
<name sortKey="Feng, Bin" sort="Feng, Bin" uniqKey="Feng B" first="Bin" last="Feng">Bin Feng</name>
<name sortKey="Geng, Yi" sort="Geng, Yi" uniqKey="Geng Y" first="Yi" last="Geng">Yi Geng</name>
<name sortKey="Huang, Chao" sort="Huang, Chao" uniqKey="Huang C" first="Chao" last="Huang">Chao Huang</name>
<name sortKey="Huang, Chao" sort="Huang, Chao" uniqKey="Huang C" first="Chao" last="Huang">Chao Huang</name>
<name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
<name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name>
<name sortKey="Li, Lixia" sort="Li, Lixia" uniqKey="Li L" first="Lixia" last="Li">Lixia Li</name>
<name sortKey="Li, Lixia" sort="Li, Lixia" uniqKey="Li L" first="Lixia" last="Li">Lixia Li</name>
<name sortKey="Liu, Wentao" sort="Liu, Wentao" uniqKey="Liu W" first="Wentao" last="Liu">Wentao Liu</name>
<name sortKey="Liu, Wentao" sort="Liu, Wentao" uniqKey="Liu W" first="Wentao" last="Liu">Wentao Liu</name>
<name sortKey="Luo, Qihui" sort="Luo, Qihui" uniqKey="Luo Q" first="Qihui" last="Luo">Qihui Luo</name>
<name sortKey="Luo, Qihui" sort="Luo, Qihui" uniqKey="Luo Q" first="Qihui" last="Luo">Qihui Luo</name>
<name sortKey="Pang, Dejiang" sort="Pang, Dejiang" uniqKey="Pang D" first="Dejiang" last="Pang">Dejiang Pang</name>
<name sortKey="Yang, Chengcheng" sort="Yang, Chengcheng" uniqKey="Yang C" first="Chengcheng" last="Yang">Chengcheng Yang</name>
<name sortKey="Yang, Chengcheng" sort="Yang, Chengcheng" uniqKey="Yang C" first="Chengcheng" last="Yang">Chengcheng Yang</name>
<name sortKey="Zou, Yuanfeng" sort="Zou, Yuanfeng" uniqKey="Zou Y" first="Yuanfeng" last="Zou">Yuanfeng Zou</name>
<name sortKey="Zou, Yuanfeng" sort="Zou, Yuanfeng" uniqKey="Zou Y" first="Yuanfeng" last="Zou">Yuanfeng Zou</name>
</country>
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Serveur d'exploration Chloroquine

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

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